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Effect of Rnase H degradation on antisense activity. Minimum mRNA levels, normalized to the initial values, as a function of the first-order rate constant for Rnase H-mediated target degradation, for moderate oligonucleotide-mRNA binding (ka = 1.0 μM−1 min−1), and for more rapid oligonucleotide-mRNA binding (ka = 10.0 μM−1 min−1).
