TABLE 3.

AP parameters and [Ca²⁺]_i dynamics for single HVMs paced at 1 Hz: model-generated values and experimentally observed values

	[Ca2+]o (mM)	[K+]o (mM)	[Na+]i* (mM)	RP (mV)	Vmax (V/s)	APD90 (ms)	[Ca2+]i,r† (nM)	Δ[Ca2+]i (nM)
Model values	2.0	4.0	10	−91.2	385	357	200	900
Priebe-Beuckelmann (15)‡	2.0	4.0	10	−90.2	386	357	400	0
Bernus et al. (18)	2.0	4.0	10	−90.4	369	333	119	784
Sachse et al. (39)	2.0	5.4	>11.5	−87.3	288	276	70	930
Ten Tusscher et al. (16)	2.0	4.0	9.80	−90.7	350	322	68	797
Iyer et al. (17)	2.0	5.4	9.18	−84.9	411	338	169	792
Current (modified) model
Experimental values
Peeters et al. (90)	1.2	4.0		−84 ± 6		381 ± 94
Li et al. (24)	1.0	5.4	10	−83 ± 3		336 ± 16
Li et al. (42)	2.0	5.4	10	−82 ± 2		298 ± 17
Péréon et al. (91), epicardium	2.7	4.0		−86 ± 1	196 ± 20	324 ± 19
Péréon et al. (91), midmyocardium	2.7	4.0		−86 ± 1	446 ± 46	432 ± 19
Piacentino et al. (92)	1.0	5.4	12.5				153 ± 20	804 ± 197

^*The steady-state mean [Na⁺]_i values during 1 Hz pacing are shown for the TNNP (16), Iyer et al. (17), and the current model; the resting state or fixed value is shown for others. The experimental values were for the perforated- or ruptured-patch recording. A [Na⁺]_i value was unknown (not shown) when the conventional microelectrode method was used.

^†Minimum [Ca²⁺]_i values during the diastolic phase, i.e., [Ca²⁺]_i values at the end of phase 4.

^‡Data for AP parameters are from Table 3 of Bernus et al. (18). The values of [Ca²⁺]_i,r (200) and Δ[Ca²⁺]_i (900) are only approximations from the original figures.

Abbreviations: RP, resting potential; V_max, maximum upstroke velocity.