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Simulated microtubule disassembly in the presence of XMAP215. Simulated disassembly, with an XMAP215-induced change in standard free energy of −3.6 kBT for longitudinal bonds, and +0.85 kBT for curling energy, promotes rapid disassembly (∼−60 μm min−1) of uncapped microtubules. Simulations were allowed to run for 500 events to produce the final states shown, which recapitulate the observed appearance of rams' horns during disassembly in the presence of XMAP215.
