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. 2005 Aug 12;89(5):3628–3638. doi: 10.1529/biophysj.104.049809

FIGURE 9.

FIGURE 9

Concentration changes in the attached region. (A and B) Impact of radius R of the attached membrane on the amplitude and time course of K+ concentration changes in the cleft for the spatial integration (A) and the point-contact approximation (B). The values of R are indicated in the figure. The following parameters were used for the calculations: cellular holding voltage Vh = +50 mV, whole cell K+ current IM = 2 nA for 100 ms, h = 50 nm, ratio 2:1 of free/attached membrane, bulk concentrations: [K+] = 5 mM, [Na+] = 140 mM, [Cl−] = 145 mM. (C and D) Impact of cleft height h on the amplitude and time course of K+ concentration changes in cleft for the spatial integration (C) and the point-contact approximation (D). Values for h are indicated in the figure; R = 10 μm. Other parameters as in panels A and B. (E) Time course of Inline graphic for the spatial integration. Parameters as in panels A and B. (F) Time course of Inline graphic for the point-contact approximation. Parameters as in panels A and B; R = 10 μm.