Skip to main content
. 2026 Oct 1;16:1919412. doi: 10.3389/fonc.2026.1919412

Figure 2.

Panel A presents a heatmap displaying standardized program scores for six immune and stromal gene programs across three COO groups (ABC, GCB, UC) among GSE31312 samples. Panel B shows six violin plots comparing standardized program scores by COO group for each program, with statistical values listed. Panel C provides a correlation heatmap illustrating Pearson correlation coefficients among program scores, with shared program memberships marked with asterisks and color indicating correlation strength.

COO-associated variation and correlation structure of continuous programs. (A) Standardized scores across 498 GSE31312 samples grouped as ABC (n=214), GCB (n=237) and UC (n=47), ordered by ascending PC1 within COO for display. (B) COO distributions with Kruskal-Wallis BH-FDR and eta-squared. (C) Pearson correlation matrix; markers identify the two pairs with shared memberships: T cell-inflamed × Antigen-presentation (2 genes) and Stromal/fibrotic × Immune-cold/exclusion (9 genes). Shared membership does not imply that covariance is caused solely by overlap. No class, centroid or taxonomy is displayed.