TABLE 3.
Posaconazole pharmacokinetic parameters on day 10
| Parameter (unit)a | Value [mean (% coefficient of variation)]
|
||
|---|---|---|---|
| Group 1 (400 mg b.i.d.) (n = 24) | Group 2 (600 mg b.i.d.) (n = 19) | Group 3 (800 mg q.d.) (n = 18) | |
| Cmax (ng/ml) | 851 (82) | 579 (71) | 361 (74) |
| Cmin (ng/ml) | 640 (98) | 388 (64) | 252 (100) |
| Cav (ng/ml) | 723 (86) | 490 (71) | 259 (72) |
| Cav, least square (ng/ml) | 523 | 333 | 184 |
| Tmax (h)b | 3.0 (0, 12.5) | 3.83 (0, 10) | 4.04 (2.42, 12.5) |
| AUCτ (ng · h/ml) | 8,619 (86) | 5,823 (71) | 6,199 (71) |
| NAUC (ng · h/ml)c | 8,619 (86) | 3,882 (71) | 3,099 (71) |
| V/F (liters) | 2,447 (421) | 4,984 (919) | 5,061 (903) |
| CL/F (liters/h) | 283 (354) | 179 (82) | 215 (81) |
| T1/2 (h) | 11.9 (3) | 12.0 (3) | 24 (2) |
a
Cmin, Trough plasma concentration; T1/2, half-life.
b
Median (minimum, maximum).
c
P value for log-transformed NAUC: 400 mg b.i.d. versus 600 mg b.i.d., P = 0.0004; 400 mg b.i.d. versus 800 mg q.d., P < 0.0001; 600 mg b.i.d. versus 800 mg q.d., P = 0.447.