TABLE 6.
Clinical response | No. (%) of patients
|
|||||||
---|---|---|---|---|---|---|---|---|
Group 1 (200 mg q.i.d./400 mg b.i.d.)
|
Group 2 (400 mg q.i.d./600 mg b.i.d.)
|
Group 3 (800 mg b.i.d./800 mg q.d.)
|
Total
|
|||||
Efficacy evaluable (n = 9) | All randomized (n = 12) | Efficacy evaluable (n = 6) | All randomized (n = 10) | Efficacy evaluable (n = 6) | All randomized (n = 10) | Efficacy evaluable (n = 21) | All randomized (n = 32) | |
Responder (complete + partial) | 5 (56) | 6 (50) | 1 (17) | 1 (10) | 3 (50) | 4 (40) | 9 (43) | 11 (34) |
Complete | 0 | 0 | 0 | 0 | 2 (33) | 3 (30) | 2 (10) | 3 (9) |
Partial | 5 (56) | 6 (50) | 1 (17) | 1 (10) | 1 (17) | 1 (10) | 7 (33) | 8 (25) |
Failure | 4 (44) | 6 (50) | 5 (83) | 9 (90) | 3 (50) | 6 (60) | 12 (57) | 21 (66) |
Stable disease | 1 (11) | 1 (8) | 1 (17) | 1 (10) | 1 (17) | 1 (10) | 3 (14) | 3 (9) |
Clinical failure | 3 (33) | 3 (25) | 2 (33) | 2 (20) | 1 (17) | 1 (10) | 6 (29) | 6 (19) |
Unable to determine | 0 | 0 | 1 (17) | 1 (10) | 1 (17) | 1 (10) | 2 (10) | 2 (6) |
Missing | 0 | 2 (17) | 1 (17) | 5 (50) | 0 | 3 (30) | 1 (5) | 10 (31) |