TABLE 1.
Inhibition of the activities of Cryptococcal neoformans (strain H99) PLB1 by miltefosine
| Enzyme fraction | % Inhibition at the indicated concna
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| LPL
|
LPTA
|
PLB
|
|||||||
| 2.5 μM | 25 μM | 250 μM | 2.5 μM | 25 μM | 250 μM | 2.5 μM | 25 μM | 250 μM | |
| Secretory enzyme | 0 | 0 | 34.3b (2.3) | 6.8b (2.7) | 35.0b (4.0) | 80.0b (2.9) | 0 | 0 | 31.7b (3.8) |
| Cytosolic enzyme | 0 | 0 | 50.7b (1.8) | 0 | 14.3b (2.7) | 77.0b (0.6) | 0 | 0 | 25.0b (4.3) |
| Membrane-bound enzyme | 0 | 0 | 0 | 0 | 11.5b (1.5) | 31.0b (1.0) | 0 | 0 | 0 |
a
Data are expressed as the means (standard error of the means) of at least three assays.
b
Significantly different (P < 0.01) from the results for the inhibitor-free controls by the Dunnett multiple-comparison test.