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In vitro rate of killing of Cryptococcus neoformans H99 by miltefosine
| Concn of miltefosine (μM) | Viable cryptococci (CFU/ml) at the following time of exposure (h)a:
|
||||
|---|---|---|---|---|---|
| 0 | 1 | 3 | 4 | 5 | |
| 700 (285 μg/ml, or 0.0285%) | 0 | 0 | 0 | 0 | 0 |
| 7.0 (2.8 μg/ml, or 0.00028%) | 1.95 × 106 | 1.23 × 106 | 1.5 × 105 | 2.7 × 104 | 2.0 × 104 |
| 0.7 (0.28 μg/ml) | 2.31 × 106 | 2.10 × 106 | 1.9 × 106 | 1.9 × 106 | 1.9 × 106 |
The number of CFU (drug-free control) at zero time was 2.5 × 106/ml.
