FIG. 1.

INH-A21 IGIV inhibits fibrinogen-binding activity of Clf40 and SdrG-A. Microtiter plates were coated with Clf40 (left) or SdrG-A (right) recombinant proteins. Serial dilutions of INH-A21 IGIV (solid triangles) or normal IGIV (open diamonds) were incubated on the plates, and the capacity for Clf40 and SdrG-A to bind fibrinogen was then measured. The percentage of fibrinogen bound compared to controls lacking the antibody inhibitors is indicated. Symbols indicate the mean ± standard deviation of duplicate determinations.