FIG. 6.
Treatment of established S. aureus (MRSA) IE. New Zealand White rabbits were catheterized to induce cardiac vegetations and injected i.v. 24 h later with 7.6 ×105 CFU MRSA 67-0. Twenty-four hours after challenge, the animals were treated with 100, 200, or 300 mg/kg INH-A21 or buffer control (buffer group, n = 4; all other groups, n = 6). Samples of vegetations, kidneys, and blood were harvested and cultured. Symbols indicate results from individual tissue samples. Horizontal lines indicate group medians. Bacterial counts were significantly reduced in blood samples at doses of 200 and 300 mg/kg (P < 0.05), in kidney samples of animals treated with 200 mg/kg (P < 0.05), and in cardiac vegetations of animals treated with 300 mg/kg (P < 0.05). Significant P values are indicated on the graphs.