Skip to main content
. 2002 Dec;76(24):12834–12844. doi: 10.1128/JVI.76.24.12834-12844.2002

FIG. 4.

FIG. 4.

Autoreactive cells are not NK cells. (a) TMEV-induced autoreactive cells were compared with various cells with NK activity. (b) NK cells were induced by intraperitoneal injection of poly(I:C). (c) LAK cells were induced by culture with IL-2 in vitro. (d) Spleen cells were incubated with bacterial DNA to induce NK cell activity. As target cells, we used the NK-sensitive cell line YAC-1 (○), the NK-resistant cell lines P815 (▵) and EL4 (□), and the syngeneic cell line PSJL (•). Poly(I:C)-induced NK cells, LAK cells and DNA-induced NK cells killed the NK-sensitive cell line, YAC-1, whereas TMEV-induced autoreactive cells did not kill YAC-1. While poly(I:C)-induced NK cells did not kill PSJL cells, LAK cells and DNA-induced NK cells killed not only PSJL cells but also the NK-resistant cell lines, P815 and EL4. Results are representative of those from four independent experiments. Error bars indicate standard errors.