TABLE 2.
Single-dose pharmacokinetic profile of anidulafungin in children with compromised immunity and neutropenia
| Parameter | Value for group with dose
|
Value for all patients (n = 24)
|
||||
|---|---|---|---|---|---|---|
| 1.5 mg/kg (n = 12)
|
3.0 mg/kg (n = 12)
|
|||||
| Ages 2-11 yr (n = 6) | Ages 12-17 yr (n = 6) | Ages 2-11 yr (n = 6) | Ages 12-17 yr (n = 6) | 1.5 mg/kg (n = 12) | 3.0 mg/kg (n = 12) | |
| Cmax (mg/ml) | ||||||
| Mean (SD) | 3.95 (0.74) | 4.10 (1.11) | 7.80 (0.76) | 5.99 (1.50) | 4.02 (0.9) | 6.90 (1.13) |
| Range | 3.04-4.91 | 2.98-6.08 | 6.93-8.97 | 4.06-7.88 | 2.98-6.08 | 4.06-8.97 |
| AUC0-24 (mg·h/ml) | ||||||
| Mean (SD) | 46.3 (8.70) | 49.6 (14.6) | 92.3 (11.9) | 87.2 (23.6) | 48.0 (11.6) | 89.7 (18.0) |
| Range | 34.7-54.1 | 40.0-78.7 | 77.4-107.5 | 56.1-119.2 | 34.7-78.7 | 56.1-119.2 |
| t1/2 (h) | ||||||
| Mean (SD) | 17.3 (3.7) | 24.3 (8.7) | 18.3 (6.7) | 20.8 (4.8) | 20.8 (6.2) | 19.5 (5.8) |
| Range | 14.7-24.7 | 13.3-36.0 | 14.2-31.8 | 17.4-29.3 | 13.3-36 | 14.2-31.8 |
| CL/kg (liters/h/kg) | ||||||
| Mean (SD) | 0.0208 (0.0052) | 0.0143 (0.0062) | 0.0200 (0.0058) | 0.0181 (0.0078) | 0.0175 (0.0057) | 0.0191 (0.0068) |
| Range | 0.0145-0.0275 | 0.0054-0.0199 | 0.0102-0.0266 | 0.0116-0.0316 | 0.0054-0.0275 | 0.0102-0.0316 |
| Vss (liters/kg) | ||||||
| Mean (SD) | 0.488 (0.086) | 0.430 (0.133) | 0.474 (0.036) | 0.523 (0.193) | 0.459 (0.110) | 0.499 (0.115) |
| Range | 0.399-0.602 | 0.267-0.610 | 0.421-0.529 | 0.375-0.857 | 0.267-0.610 | 0.375-0.857 |