TABLE 2.
PK/PD parameters and pulmonary fungal burden in immunosuppressed mice with IPA
| AMB dose (mg/kg) and interval | Cmax/MIC ratio | 24-h AUC/MIC ratio | % Time above MIC (over 72 h) | Mean CE (SE) |
|---|---|---|---|---|
| Control | 6.79 (0.38) | |||
| 0.167 q8h | 0.28 | 11.6 | 0 | 6.12 (0.39) |
| 0.5 q24h | 0.80 | 12.4 | 1.4 | 5.12 (0.58) |
| 1.5 q72h | 2.4 | 13.6 | 20.8 | 4.12 (0.50) |
| 0.25 q8h | 0.40 | 17.2 | 4.2 | 5.98 (0.48) |
| 0.75 q24h | 1.2 | 18.8 | 26.4 | 5.78 (0.47) |
| 2.25 q72h | 3.56 | 20.4 | 30.6 | 4.20 (0.35) |
| 0.33 q8h | 0.52 | 22.8 | 43.1 | 5.24 (0.59) |
| 1 q24h | 1.6 | 25.2 | 47.2 | 4.60 (0.79) |
| 3 q72h | 4.76 | 27.6 | 36.1 | 3.71 (0.34) |