TABLE 2.
Drug | Dose (mg/kg) | Plasma concn (μM)a
|
||
---|---|---|---|---|
Saquinavir | Ritonavir | Lopinavir | ||
Saquinavir | 5 | 0 | ||
Ritonavir | 10 | 0 | ||
50 | 10.1 | |||
Saquinavir-ritonavir | 5/50 | 0.5 | 12.7 | |
10/5 | 0.1 | 0 | ||
10/10 | 1.7 | 2.6 | ||
10/50 | 1.3 | 7.6 | ||
Lopinavir-ritonavirb | 10/2.5 | 0 | 0 | |
20/5 | 0 | 0.5 | ||
40/10 | 0 | 5.3 |
Ritonavir, saquinavir, and lopinavir concentrations were measured from the pooled plasma of three mice 4 hours after oral administration.
Administered as lopinavir-ritonavir (Kaletra).