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Inhibitory activities of 3,5-dioxopyrazolidines against peptidoglycan-synthetic enzymes
| Compound | IC50 (μM) against:
|
||||||
|---|---|---|---|---|---|---|---|
| E. coli MurA | E. coli MurB | S. aureus MurB | E. coli MurC | E. coli MurD | E. coli MurE | E. coli MurE-F | |
| 1 | 21.6 | 4.1 | 4.3 | >50 | >50 | >50 | >50 |
| 2 | 6.8 | 5.3 | 10.3 | 36.0 | >50 | >50 | >50 |
| 3 | 29.4 | 6.8 | 5.1 | >50 | >50 | >50 | >50 |
| 4 | >50 | 35.0 | 24.5 | 29.2 | >50 | >50 | >50 |
| Fosfomycin | 35.0 | >300 | >300 | >300 | >300 | >300 | >300 |
