TABLE 3.
Comparative in vivo efficacies of AMB, L-AMB, and ABLC against five C. albicans isolates
| C. albicans strain | Efficacy (mg/kg/24 h [95% CI])
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMB
|
L-AMB
|
ABLC
|
||||||||||
| ED25 | ED50 | ED75 | ED for 1-log killing | ED25 | ED50 | ED75 | ED for 1-log killing | ED25 | ED50 | ED75 | ED for 1-log killing | |
| K1 | 0.34 (0.33-0.35) | 1.49 (1.45-1.53) | 6.35 (6.17-6.52) | 5.06 (4.91-5.21) | 2.05 (1.95-2.15) | 3.94 (3.74-4.14) | 7.59 (7.21-7.97) | 11.40 (10.8-12.0) | 2.42 (2.05-2.78) | 4.11 (3.49-4.73) | 7.00 (6.00-8.00) | 14.8 (12.6-17.0) |
| 98-17 | 0.29 (0.18-0.40) | 1.91 (1.19-2.63) | 12.5 (7.7-17.3) | 11.8 (6.87-16.7) | 1.16 (1.11-1.21) | 2.63 (2.52-2.64) | 6.03 (5.79-6.27) | 15.8 (15.2-16.4) | 2.46 (2.36-2.56) | 3.97 (3.80-4.15) | 6.43 (6.15-6.71) | 6.02 (5.78-6.26) |
| 98-234 | 0.14 (0.10-0.18) | 0.25 (0.17-0.33) | 0.42 (0.29-0.55) | 10.84 (7.44-14.2) | 1.03 (0.53-1.54) | 3.01 (1.34-4.67) | 8.79 (4.40-12.3) | 23.5 (21.8-25.2) | 2.08 (0.65-3.49) | 3.31 (1.03-5.59) | 5.26 (1.68-8.84) | 45 (15-60) |
| 3588 | 0.17 (0.14-0.20) | 0.70 (0.59-0.81) | 2.92 (2.42-3.42) | 5.31 (4.42-6.20) | 0.46 (0.38-0.54) | 3.78 (3.10-4.46) | 31.5 (25.8-37.2) | 28.5 (23.3-33.7) | 0.85 (0.21-1.49) | 2.22 (0.46-3.98) | 5.81 (1.40-10.2) | 14.7 (5.60-25.9) |
| 5810 | 0.04 (0.03-0.05) | 0.15 (0.12-0.18) | 0.57 (0.46-0.68) | 2.09 (1.68-2.51) | 1.27 (1.09-1.44) | 3.23 (2.78-3.68) | 8.21 (7.06-9.36) | 15.0 (12.9-17.1) | 0.30 (0.23-0.37) | 0.58 (0.45-0.71) | 1.08 (0.84-1.32) | 3.45 (2.69-4.21) |