TABLE 1.
Effects of the specific mitochondrial inhibitors AA and BHAM at inhibitory concentrations on CAS and FLC MICs against three clinical isolates of C. parapsilosis in RPMI mediuma
Isolate | Median MICb (μg/ml) of the following drug with:
|
|||||||
---|---|---|---|---|---|---|---|---|
No inhibitor
|
AA (2 μM)
|
BHAM (4 mM)
|
AA + BHAM (2 μM + 4 mM)
|
|||||
CAS | FLC | CAS | FLC | CAS | FLC | CAS | FLC | |
C. parapsilosis 2537 | 2 | >64.0 | 2 | 32.0 | 2 | >64.0 | 0.06 | 32.00 |
C. parapsilosis 2582 | 2 | 0.5 | 2 | 0.5 | 1 | 0.5 | 0.06 | 0.25 |
C. parapsilosis 2587 | 2 | 0.5 | 1 | 0.5 | 2 | 0.5 | 0.06 | 0.50 |
CLSI broth microdilution method M27-A2.
The range of MICs was less than 1 dilution in all experiments.