TABLE 2.
Effect of p53 status on epithelial hyperplasia in K14E6WT and K14E6I128T mice
| Mouse strain | Suprabasal BrdU-positive cellsa (% [avg ± SD])
|
|
|---|---|---|
| p53+/+ | p53−/− | |
| K14E6WT line 5737 | 5.0 ± 0.1 | NDb |
| K14E6I128T line 6072 | 1.3 ± 0.5 | 1.4 ± 0.1 |
| K14E6I128T line 6061 | 2.9 ± 1.1 | 1.7 ± 0.6 |
a
Percentages of suprabasal cells that were BrdU positive in ear sections of 9-day-old mice. For details, see Table 1. Values represent the averages for three mice per genotype ± 1 standard deviation.
b
ND, not determined. Previous analysis indicated no differences in the degree of epidermal hyperplasia in the ears of 6-week-old K14E6WT mice of the p53-sufficient versus p53-null background (see reference 40).