TABLE 1.

Porphyrins as prophylactic compounds against 263K scrapie infection

Compound	i.p. dose [mg/kg (mmol/kg)]a	Dosing regimen	i.p. scrapie inoculation (day 0)b	Survival times (days)c	Mean survival time ± SD
None			50 μl 1% BH	78, 82, 91, 91, 92, 92, 92, 92, 100	90.0 ± 6.4
FeTSP	12.5 (0.012)	3 doses/wk for 6 wks starting 2 wks prior to inoculation	50 μl 1% BH	124, 143, 145, 147, 163, 171, 196, 203	161.5 ± 27.3d
TSP	25 (0.025)	Dosing on days −2, −1, and 0, then 3 doses/wk for 5 wks	50 μl 1% BH	119, 122, 122, 126, 129, 136, 141, 161	132.0 ± 13.9d
FeTAP	12.5 (0.012)	3 doses/wk for 6 wks starting 2 wks prior to inoculation	50 μl 1% BH	295, 299, 376, 388, 581, 686	437.5 ± 160.0d
TAP	6.25 (0.006)e	3 doses/wk for 6 wks starting 2 wks prior to inoculation	50 μl 1% BH	100, 127, 142, 156, 182, 183, 205, 233	166.0 ± 43.3d

^aIn phosphate-buffered saline.

^bBH, 263K-infected brain homogenate in phosphate-buffered saline.

^cTg7 mice dying from nonscrapie causes were removed from the data set.

^dP < 0.0001 versus control group by unpaired t test.

^eThe dose of 12.5 mg/kg was toxic.