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. 2005 Dec;89(6):3673–3675. doi: 10.1529/biophysj.105.071563

FIGURE 1.

FIGURE 1

The simple del Castillo-Katz mechanism (A = agonist, R = receptor), and its extension by addition of five intermediate preopening states. Boxed regions are fully liganded. The REFER plots calculated from the numerical example in Zhou et al. (2) are shown (bottom left) and the corresponding Φ-values are plotted against the gating constant (bottom right). Calculations are shown for perturbation of the first (m = 1), third (m = 3), and fifth (m = 5) intermediate states (Xm), as in Zhou et al. (2).