TABLE 2.

Summary of effects of nectin-1 and nectin-2 mutations

Protein	Viral entry					Nectin-nectin interactions
	HSV-1	HSV-1 Rid1	HSV-2	PRV	BHV-1	Homotypic	Heterotypic with nectin-3
Nectin-1
Wild type	+a	+	+	+	+	+	+
QN76-    77AA;     M85F	⇊	⇊	⇊	+	+	+	+
R110P	↓	↓	↓	⇊	⇊	⇊	⇊
F129L	+	+	+	↓	⇊	↓	+
Nectin-2
Wild type	NAb	+	+	+	NA	+	NDc
M89F	NA	⇊	⇊	+	NA	+	ND
A126P	NA	⇊	⇊	⇊	NA	⇊	ND
F145L	NA	⇊	↓	⇊	NA	⇊	ND

^aA plus sign indicates that activity is equivalent to that observed for wild-type nectin-1 or nectin-2. One or two downward arrows denote somewhat or drastically reduced levels of activity, respectively.

^bNA, wild-type nectin-2 is not able to mediate entry of some of the viruses used.

^cND, not determined.