TABLE 1.

Network parameters of thermophilic and mesophilic proteins

		Thermophile PDBid	Mesophile PDBid		No. of hubs		Total No. of edges		Edge/node ratio		Largest cluster size
Serial No.	Protein			Imin	T*	M†	T	M	T	M	T	M
1	TATA box binding protein	1PCZ	1VOK	0	59	52	326	325	1.75	1.69	165‡	174‡
				2	22	13	220	214	1.20	1.11	147	101
				4	8	1	139	124	0.76	0.65	35	32
2	Adenylate kinase	1ZIP	1AK2	0	75	54	376	316	1.73	1.44	184	170
				2	21	20	238	211	1.10	0.96	158	121
				4	5	4	134	127	0.62	0.58	57	29
3	Subtilisin	1THM	1ST3	0	95	89	521	481	1.87	1.78	262	247
				2	26	25	310	300	1.12	1.10	213	184
				4	2	1	152	150	0.56	0.54	47	29
4	Carboxy peptidase	1OBR	2CTC	0	149	135	661	635	2.05	2.01	298	290
				2	64	61	468	451	1.45	1.42	278	272
				4	12	8	295	269	0.91	0.88	214	129
5	Neutral protease	1THL	1NPC	0	116	109	582	560	1.84	1.77	290	287
				2	41	40	407	384	1.29	1.21	238‡	260‡
				4	4‡	7‡	242	229	0.77	0.72	101	72
6	Phosphofructo kinase	3PFK	2PFK	0	89	87	524	506	1.64‡	1.69‡	275	267
				2	20	15	334	332	1.05‡	1.11‡	238	232
				4	0	0	165‡	180‡	0.52‡	0.60‡	62	49
7	Lactate dehydrogenase	1LDN	1LDM	0	104	95	541	524	1.71	1.59	277	267
				2	27	19	353	317	1.12	0.96	219	209
				4	3	2	198	169	0.63	0.51	97	95
8	Glyceraldehyde-3-phosphate dehydrogenase	1GD1	1GAD	0	108	103	577	553	1.74	1.69	294	284
				2	38	35	373	352	1.13	1.08	229	220
				4	9	3	201	188	0.61	0.57	57	49
9	Phosphoglycerate kinase	1PHP	3PGK	0	146	80	739	526	1.88	1.27	363	313
				2	45	24	451	353	1.14	0.85	282	205
				4	3‡	5‡	217‡	226‡	0.55	0.53	55	52
10	Reductase	1EBD	1LVL	0	115	127	725	713	1.59	1.56	412	367
				2	33	22	461	417	1.01	0.91	232	181
				4	3	2	236	209	0.52	0.46	27	22

^*T, thermophile.

^†M, mesophile.

^‡Cases where the values are higher for the mesophilic protein than the corresponding thermophilic protein.