TABLE 2.
| Protein (No. of hubs in thermophile, No. of hubs in mesophile at Imin = 4%)
|
Common hubs‡ in thermophile and mesophile
|
Exclusive hubs‡
|
|
|---|---|---|---|
| Thermophile | Mesophile | ||
| TATA box bindingprotein (1,8) | – | F94, F107,L124, E177 | F185 |
| Adenylate kinase (4,5) | – | F81, Y191 | H146, D166 |
| Subtilisin (1,2) | – | I78 | D121 |
| Carboxy peptidase (8,12) | H204(H196), Y214(Y206), Y266(Y259)§ | H68, Y149, R189, F233, N301 | W73, L271, R272 |
| Neutral protease (4,7) | Y83(Y84) | –¶ | –¶ |
| Phosphofructo kinase (0,0)‖ | – | – | – |
| Lactate dehydrogenase (2,3) | – | Y145 | N164 |
| Glyceraldehyde-3-phosphate dehydrogenase (3,9) | F16(F16), H108(H108), N236(N236) | R195 | – |
| Phosphoglycerate kinase (3,5) | – | H153 | F194 |
| Reductase (2,3) | K399(390R) | F364 | L214 |
*
Note that the numbers of mesophilic sequences are much higher than the thermophilic sequences in each family.
†
All hubs are strong hubs identified at Imin = 4%.
‡
The definition of common hubs and exclusive hubs are given in the text.
§
Residue name and number of the common hubs in the mesophile is given within parentheses.
¶
No exclusive hubs in neutral protease at Imin = 4%.
‖
No hubs are found in phosphofructo kinase at Imin = 4%.