TABLE 2.

Comparison of ion permeability between wild-type Cx46 and CxL35G

γ (pS)	Wild-type cx46	Cx46L35G
γKGlu	312 ± 10 (8)	377 ± 5 (7)
γKCl	359 ± 6 (8)	489 ± 11 (5)
pK/pGlu	4 ± 1 (4)	5 ± 1 (3)
pK/pCl	21 ± 2 (4)	25 (2)
pGlu/pCl	5	5

Single-channel conductance (pS) in 140 mM symmetric KGlu and KCl are listed in the first and second row, respectively. Permeability (p) ratio of K⁺/Glu⁻, K⁺/Cl⁻, and Glu⁻/Cl⁻ are listed in the subsequent rows. Data are shown as mean ± SD (number of channels analyzed).