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Effect of sucrose on single-channel currents of Cx46 (a), Cx46M137 (b), and Cx46L35G (c) channels. Representative recordings of the same channels contained in excised membrane patches before (top trace) and with (bottom trace) 100 mM sucrose perfusion are shown. Open (o) and closed (c) states are indicated by dotted lines. All-point amplitude histograms and single-channel conductance are shown on the side of each record.
