1. IC50 Values of Chalcones for Protease Activity Evaluated under Cysteine Protease and Serine Protease Conditions in Protein Extracts from Stationary-Phase Promastigotes Leishmania(V.)braziliensis .
| IC50 (mM) |
||
|---|---|---|
| compounds | sodium acetate buffer pH 5.5 | Tris–HCl buffer pH 7.5 |
| TMC | 0.096 ± 0.019 | 0.122 ± 0.0060 |
| 3a | 0.164 ± 0.012 | 0.073 ± 0.0330 |
| 3b | 0.088 ± 0.010 | 0.057 ± 0.0140 |
| 3c | 0.082 ± 0.004 | 0.107 ± 0.0040 |
| 3d | 0.068 ± 0.009 | 0.071 ± 0.0260 |
| 3e | 0.076 ± 0.027 | 0.020 ± 0.0100 |
| 3f | 0.082 ± 0.010 | 0.143 ± 0.0270 |
| 3g | 0.132 ± 0.008 | 0.039 ± 0.0160 |
| 3h | 0.178 ± 0.018 | 0.111 ± 0.0150 |
| 3i | 0.056 ± 0.018 | 0.010 ± 0.0004 |
| 3j | 0.076 ± 0.011 | 0.010 ± 0.0010 |
a
Half-maximal inhibitory concentration (IC50); 2′,4′,6′-trimethoxy-chalcone (TMC).