2. In Vitro Effects of Chalcones on Promastigote Forms of Leishmania(V.)braziliensis and on Murine Peritoneal Macrophages .
| compounds | promastigote IC50 (μM) | macrophage CC50 (μM) | SI |
|---|---|---|---|
| TMC | 7.31 ± 1.53 | 160.01 ± 6.92 | 21.88 |
| 3a | 14.16 ± 0.79 | 45.62 ± 8.61 | 3.22 |
| 3b | 7.66 ± 0.84 | 136.3 ± 18.62 | 17.79 |
| 3c | 8.02 ± 1.34 | 40.03 ± 4.22 | 4.99 |
| 3d | 9.76 ± 2.43 | 163.45 ± 3.04 | 16.74 |
| 3e | 29.73 ± 2.24 | 35.80 ± 4.98 | 1.20 |
| 3f | 3.352 ± 0.05 | 25.38 ± 2.71 | 7.57 |
| 3g | 5.97 ± 1.11 | 25.61 ± 1.43 | 4.28 |
| 3h | 8.08 ± 0.29 | 177.06 ± 10.66 | 21.91 |
| 3i | 2.08 ± 0.24 | 213.23 ± 7.91 | 102.17 |
| 3j | 13.25 ± 1.49 | 37.87 ± 7.75 | 2.85 |
| amphotericin B | 0.38 ± 0.09 | 67.88 ± 0.94 | 178.63 |
a
Selectivity index (SI); half-maximal inhibitory concentration (IC50); half-maximal cytotoxic concentration (CC50); 2′,4′,6′-trimethoxy-chalcone (TMC).