TABLE 2.

Key residues in pol X and analogues in pol β

Residue in pol X	Residue in pol β	Comments
Asp-49	Asp-190	Catalytic triad: Asp-100 flips and coordinates to Lys-85 and Gln-98
Asp-51	Asp-192
Asp-100	Asp-256
Lys-85	Lys-234	Conserved Lys residue: flips and forms H-bond with Asp-100 during the dynamics
Phe-102	Arg-258	Flips after Phe-116
His-115	Tyr-271	Both flip at the beginning of the dynamics
Phe-116	Phe-272
Val-120	Asp-276	Its flip initiates the thumb movement