TABLE 2.

ONYX-015 replication is independent of p53 and p14^ARF status^a

Cell type	wt Ad5		ONYX-015
	CPE (U/ml)	PFU/ml	CPE (U/ml)	PFU/ml
A549	7.5 × 109	2.0 × 1010	2.0 × 109	6.0 × 109
RKO	7.5 × 109	1.8 × 1010	7.5 × 108	2.0 × 109
RKO p53.13	7.5 × 109	1.5 × 1010	6.0 × 109	6.0 × 109
HDF	3.8 × 107	NDb	None	ND
Bre80	2.2 × 108	ND	1.7 × 108	ND

^aCPE and plaque-forming assays were carried out as described in Methods and Materials.

^bND, not determined.