Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Ca2+-release and [3H]ryanodine-binding properties of wild-type and mutant RyR1s
| Name | Caffeine-induced Ca2+ release | [3H]Ryanodine binding |
|---|---|---|
| Vector | − | − |
| Wild-type RyR1 | +++ | +++ |
| D4938N | +++ | +++ |
| E4942Q | − | − |
| D4945N | +++ | +++ |
| E4948Q | +++ | + |
| E4952Q | +++ | +++ |
| D4953N | − | − |
| E4955Q | +++ | +++ |
(+++) indicates caffeine-induced Ca2+ release and [3H]ryanodine binding activities comparable to wild-type RyR1; (+) indicates reduced activity; and (−) indicates no activity.
