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. 2002 Dec;76(24):12423–12434. doi: 10.1128/JVI.76.24.12423-12434.2002

FIG. 1.

FIG. 1.

Phenotypic analysis of HBV- and HCV-specific CTL. (A) Representative dot plot analyses of HBV and HCV tetramer-positive cells stained with anti-CD8, anti-CCR7, anti-CD27, and anti-CD45RA monoclonal antibodies. (B) Percentages of CCR7− (top) and CD45RA− CCR7− (bottom) cells among HBV tetramer-positive CD8 lymphocytes specific for core 18-27, envelope 335-343, and polymerase 575-583 epitopes and among HCV tetramer-positive CD8 cells specific for NS3 1073-1081, NS3 1406-1415, and NS4B 1992-2000 epitopes in each patient (Pt) with acute HBV and HCV infection. (C) Percentages of CD27+ cells among CCR7− CD45RA− tetramer-positive CD8 cells in each patient with acute HBV and HCV infection. (∗), frequency of tetramer-positive cells was <0.01% of CD8+ cells; NT, not tested.