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. 2026 Oct 1;13:1950636. doi: 10.3389/fmed.2026.1950636

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© 2026 Zhang, Cao, Zheng, Yang, Guan, Zheng, Yang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Four line graphs display tumor marker trends (CA125, CA15-3, CYFRA21-1, NSE) from April 2025 to March 2026, showing sharp increases above upper normal limits by early 2026. Below, a timeline details clinical events, treatments, disease progression, and death over the same period. — Tumor marker trends and clinical timeline. Panel A shows changes in CA125, CA15-3, CYFRA21-1, and NSE during the disease course. Panel B summarizes the main diagnostic, therapeutic, progression, and outcome events.