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(a) The native structure and enthalpic and entropic parameters of the native state for sequence UAUAUCGCnCGAUAUA. The shaded stack is the rate-limiting stack s*. (b) The pathway conformations Ui and Ni (i = 1, 2, … , 20) in the respective clusters U and N, the corresponding intercluster pathways Ui ↔ Ni, and the rate constants.
