TABLE 1.
Protection against murine RV challenge conferred by two rectal immunizations with RV VLP
| Immunogen | None (RPMI medium)
|
8-2/6/7-VLP
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Adjuvant | None | Any toxina | None | CT | LT(R192G) | LT(R72) | LT(K63) | CpG | Resiquimod |
| No. of nonshedding mice/total no. of miceb | 0/7 | 0/20 | 0/5 | 6/6 | 7/7 | 6/6 | 5/7 | 1/7 | 1/5 |
| Pc | NSd | 0.0023 | 0.0013 | 0.0023 | 0.0256 | NS | NS | ||
a
Mice were immunized with each of the following toxin adjuvants given alone: CT, LT(R192G), LT(R72), or LT(K63) (n = 5 per group).
b
From the groups of mice vaccinated with VLP, one mouse each in the CT and LT(R72) groups and two mice in the resiquimod group died before challenge.
c
Significance of the chi square test between vaccinated and mock-immunized (no VLP) groups.
d
NS, no significant difference.