TABLE 2.
RV antibody responses of mice after rectal immunization with RV VLP
| Immunogen | None (RPMI medium) | 8-2/6/7-VLPb
|
||||||
|---|---|---|---|---|---|---|---|---|
| Adjuvant | None | None | CT | LT(R192G) | LT(R72) | LT(K63) | CpG | Resiquimod |
| No. of micea with: | ||||||||
| Saliva IgA | 0 | 0 | 3 | 7** | 1 | 0 | 2 | 2 |
| Stool IgA | 0 | 0 | 7** | 7** | 7** | 7** | 5* | 5* |
| Serum IgA | 0 | 2 | 6** | 7** | 7** | 5* | 5* | 2 |
| Serum IgG | 0 | 1 | 7** | 7** | 6** | 5* | 5* | 3 |
| Total no. of mice | 7 | 5 | 7 | 7 | 7 | 7 | 7 | 6 |
a
Number of mice with a detectable IgA (≥10) or IgG (≥100) RV antibody response 15 days after the second immunization (D30).
b
Significant differences between vaccinated and mock-immunized groups (RPMI medium) as measured by the chi square test: *, 0.01 ≤ P < 0.03; **, 0.001 ≤ P < 0.01.