TABLE 3.

Correlation between humoral immune responses and protection in vaccinated mice

Parameter	No. of micea with:
	Saliva IgA		Fecal IgA		Serum IgA		Serum IgG
	Positive (≥10)	Negative (<10)	Positive (≥10)	Negative (<10)	Positive (≥10)	Negative (<10)	Positive (≥100)	Negative (<100)
No. of miceb:
Protected	11	15	26	0	25	1	24	2
Nonprotected	3	14	9	8	6	11	7	10
P (chi square test)	NSc		<10−3		<10−4		<10−3

^aRV-specific antibodies were measured 15 days after the second immunization (D30).

^bProtection as judged by RV detection in stool samples over the 8-day period after RV challenge: protected, negative for RV; nonprotected, at least one stool sample positive for RV.

^cNS, no significant difference.