TABLE 5.
Selected list of genes up-regulated in SBLTCE compared to SBLiE
| GenBank accession no. | Gene description | Symbol | Relative expression level (fold) (median, >1.5) for hybridization:
|
Mean | ||
|---|---|---|---|---|---|---|
| K | L | M | ||||
| NM_000138 | Fibrillin 1 (Marfan syndrome) | FBN1 | 7.054 | 4.372 | 4.579 | 5.335 |
| AA425489 | Cartilage paired-class homeoprotein 1 | CART1 | 3.238 | 3.985 | 4.498 | 3.907 |
| AL541088 | Epithelial membrane protein 3 | EMP3 | 2.474 | 3.517 | 3.537 | 3.176 |
| BC002827 | Tropomyosin 4 | TPM4 | 1.000 | 3.679 | 2.146 | 2.913 |
| BF432072 | ATPase, Ca2+ transporting, plasma membrane 1 | ATP2B1 | 3.718 | 2.368 | 2.359 | 2.815 |
| BE856759 | Scaffold attachment factor B2 | SAFB2 | 1.000 | 2.973 | 2.608 | 2.791 |
| AW418782 | Butyrate response factor 2 | BRF2 | 2.381 | 3.207 | 2.601 | 2.730 |
| BE502910 | Nebulette | NEBL | 2.841 | 1.986 | 3.151 | 2.659 |
| AL536030 | Protein phosphatase 2, regulatory subunit B (PR 52), beta isoform | PPP2R2B | 2.754 | 2.221 | 2.850 | 2.608 |
| BG163850 | Caldesmon 1 | CALD1 | 1.954 | 2.791 | 3.040 | 2.595 |
| AU142452 | Lactate dehydrogenase A | LDHA | 2.401 | 2.571 | 2.542 | 2.505 |
| AA477295 | Activated RNA polymerase II transcription cofactor 4 | PC4 | 2.278 | 3.096 | 2.104 | 2.493 |
| AA682502 | BCL2 like 11 (apoptosis facilitator) | BCL2L11 | 2.205 | 2.174 | 2.532 | 2.304 |
| BF311786 | Hexokinase 1 | HK1 | 2.128 | 2.368 | 2.368 | 2.288 |
| BF978116 | Cell division cycle associated 8 | CDCA8 | 2.785 | 1.920 | 2.080 | 2.261 |
| AL527028 | Solute carrier family 25 (mitochondrial carrier), member 6 | SLC25A6 | 2.547 | 2.018 | 2.148 | 2.238 |
| AA283746 | Tropomyosin 2 (beta) | TPM2 | 2.540 | 2.178 | 1.925 | 2.214 |
| BE502193 | Glioblastoma amplified sequence | GBAS | 2.575 | 2.026 | 1.975 | 2.192 |
| NM_014767 | Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | SPOCK2 | 2.400 | 1.881 | 2.069 | 2.117 |
| W25414 | Tubulin, gamma complex-associated protein 2 | TUBGCP2 | 1.989 | 2.253 | 2.075 | 2.105 |
| AA075945 | Chaperonin containing TCP1, subunit 7 (eta) | CCT7 | 2.749 | 1.679 | 1.804 | 2.078 |
| NM_015185 | Cdc42 guanine nucleotide exchange factor 9 | ARHGEF9 | 2.174 | 1.920 | 2.080 | 2.058 |
| NM_002129 | High-mobility group box 2 | HMGB2 | 2.371 | 1.841 | 1.917 | 2.043 |
| NM_000019 | Acetyl coenzyme A acetyltransferase 1 (acetoacetyl coenzyme A thiolase) | ACAT1 | 2.500 | 1.915 | 1.664 | 2.026 |
| AL555167 | Signal peptidase complex (18 kDa) | SPC18 | 2.594 | 1.827 | 1.631 | 2.017 |
| BE740909 | ADP-ribosyltransferase [NAD+; poly(ADP-ribose) polymerase] | ADPRT | 2.686 | 1.665 | 1.684 | 2.012 |
| NM_003670 | Basic helix-loop-helix domain containing, class B, 2 | BHLHB2 | 2.470 | 1.624 | 1.932 | 2.009 |
| NM_002835 | Protein tyrosine phosphatase, non-receptor type 12 | PTPN12 | 2.440 | 1.902 | 1.668 | 2.004 |
| NM_001675 | Activating transcription factor 4 (Tax-responsive enhancer element B67) | ATF4 | 2.127 | 1.939 | 1.908 | 1.991 |
| BG032173 | Heat shock protein 60 (P60 lymphocyte protein) | HSPD1 | 2.719 | 1.653 | 1.600 | 1.991 |
| AA910081 | Early B-cell factor | EBF | 2.135 | 2.127 | 1.682 | 1.981 |
| BF239180 | SMC4 structural maintenance of chromosome 4-like 1 (yeast) | SMC4L1 | 2.420 | 1.751 | 1.696 | 1.956 |
| AL119232 | PTK2 protein tyrosine kinase 2 | PTK2 | 2.296 | 1.757 | 1.811 | 1.955 |
| AL556879 | RNA-binding motif protein 5 | RBM5 | 2.435 | 1.789 | 1.576 | 1.933 |
| BE252062 | Coronin, actin-binding protein, 1A | CORO1A | 1.821 | 2.063 | 1.875 | 1.920 |
| BE880168 | Integrin, beta 1 (fibronectin receptor, beta polypeptide) | ITGB1 | 2.347 | 1.868 | 1.542 | 1.919 |
| AA737229 | Small nuclear ribonucleoprotein polypeptide F | SNRPF | 2.752 | 1.320 | 1.681 | 1.918 |
| AA313584 | Eukaryotic translation initiation factor 3, subunit 3 gamma, 40 kDa | EIF3S3 | 2.136 | 1.881 | 1.729 | 1.915 |
| AU120178 | Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67 kDa | EIF3S7 | 2.102 | 1.938 | 1.702 | 1.914 |
| BG527737 | Breast carcinoma amplified sequence 2 | BCAS2 | 2.445 | 1.583 | 1.684 | 1.904 |
| AK025306 | CDC-like kinase 1 | CLK1 | 2.235 | 1.999 | 1.461 | 1.898 |
| BG399003 | ADP-ribosylation factor-like 6-interacting protein | ARL6IP | 2.506 | 1.670 | 1.485 | 1.887 |
| AI889521 | Ras homolog enriched in brain 2 | RHEB2 | 1.701 | 2.032 | 1.926 | 1.887 |
| AA452724 | Programmed cell death 5 | PDCD5 | 2.586 | 1.375 | 1.691 | 1.884 |
| AU124605 | Chaperonin-containing TCP1, subunit 4 (delta) | CCT4 | 2.475 | 1.578 | 1.567 | 1.873 |
| NM_005886 | Katanin p80 (WD repeat-containing) subunit B1 | KATNB1 | 2.432 | 1.346 | 1.826 | 1.868 |
| NM_015640 | PAI-1 mRNA-binding protein | PAI-RBP1 | 2.109 | 1.900 | 1.562 | 1.857 |
| AU120518 | Proliferation-associated 2G4, 38 kDa | PA2G4 | 2.241 | 1.611 | 1.679 | 1.844 |
| AL530970 | Nonmetastatic cells 1, protein (NM23A) expressed in | NME1 | 2.160 | 1.919 | 1.444 | 1.841 |
| BE535239 | Heterogeneous nuclear ribonucleoprotein A0 | HNRPA0 | 2.300 | 1.652 | 1.562 | 1.838 |
| BE408610 | Myeloid cell leukemia sequence 1 (BCL2 related) | MCL1 | 1.982 | 1.435 | 2.046 | 1.821 |
| BC000196 | Cyclin G1 | CCNG1 | 2.311 | 1.525 | 1.593 | 1.810 |
| NM_000922 | Phosphodiesterase 3B, cyclic GMP inhibited | PDE3B | 1.819 | 1.774 | 1.820 | 1.804 |
| AA861789 | Leukocyte receptor cluster member 5 | LENG5 | 2.006 | 1.742 | 1.634 | 1.794 |
| AU135444 | CDC10 cell division cycle 10 homolog (S. cerevisiae) | CDC10 | 2.072 | 1.800 | 1.509 | 1.794 |
| NM_003286 | Topoisomerase (DNA) I | TOP1 | 1.933 | 1.776 | 1.664 | 1.791 |
| NM_003601 | SWI/SNF-related regulator of chromatin, subfamily a, member 5 | SMARCA5 | 2.398 | 1.435 | 1.530 | 1.788 |
| NM_004703 | Rabaptin-5 | RAB5EP | 2.318 | 1.664 | 1.364 | 1.782 |
| AB020723 | Protein associated with Myc | PAM | 1.871 | 1.904 | 1.495 | 1.757 |
| BG029685 | CUG triplet repeat, RNA-binding protein 1 | CUGBP1 | 1.961 | 1.689 | 1.607 | 1.752 |
| BG473688 | AHNAK nucleoprotein (desmoyokin) | AHNAK | 2.098 | 1.512 | 1.632 | 1.748 |
| M20642 | Myosin, light polypeptide 1, alkali; skeletal, fast | MYL1 | 1.795 | 1.593 | 1.854 | 1.747 |
| NM_003156 | Stromal interaction molecule 1 | STIM1 | 2.157 | 1.572 | 1.508 | 1.745 |
| BE268036 | Polymerase (RNA) II (DNA-directed) polypeptide B, 140 kDa | POLR2B | 2.132 | 1.530 | 1.567 | 1.743 |
| AW241775 | RNA-binding motif protein 15 | RBM15 | 2.019 | 1.402 | 1.800 | 1.740 |
| AW189528 | LIM and SH3 protein 1 | LASP1 | 2.211 | 1.786 | 1.170 | 1.722 |
| BF305705 | Histone deacetylase 5 | HDAC5 | 1.674 | 1.965 | 1.522 | 1.721 |
| X72889 | SWI/SNF-related regulator of chromatin, subfamily a, member 2 | SMARCA2 | 2.095 | 1.531 | 1.528 | 1.718 |
| BF439104 | DNA (cytosine-5)-methyltransferase 1 | DNMT1 | 1.658 | 1.945 | 1.547 | 1.717 |
| D86550 | Dual-specificity tyrosine (Y) phosphorylation-regulated kinase 1A | DYRK1A | 1.725 | 1.855 | 1.530 | 1.703 |
| AI827301 | Vascular endothelial growth factor | VEGF | 1.723 | 1.916 | 1.455 | 1.698 |
| AA312869 | Vaccinia-related kinase 1 | VRK1 | 1.734 | 1.633 | 1.724 | 1.697 |
| AJ006412 | Translation initiation factor IF2 | IF2 | 2.024 | 1.575 | 1.414 | 1.671 |
| BG032225 | Integrin cytoplasmic domain-associated protein 1 | ICAP-1A | 1.568 | 1.730 | 1.699 | 1.665 |
| AI184621 | Methionyl aminopeptidase 2 | METAP2 | 1.742 | 1.459 | 1.775 | 1.659 |
| AV714317 | TGFB inducible early growth response | TIEG | 1.494 | 1.904 | 1.574 | 1.657 |
| NM_003600 | Serine/threonine kinase 6 | STK6 | 2.038 | 1.722 | 1.211 | 1.657 |
| NM_014751 | Metastasis suppressor 1 | MTSS1 | 1.551 | 1.762 | 1.000 | 1.656 |
| BE467537 | Cyclin-dependent kinase 8 | CDK8 | 1.557 | 1.802 | 1.579 | 1.646 |
| BG178769 | Histone acetyltransferase 1 | HAT1 | 1.826 | 1.806 | 1.296 | 1.643 |
| NM_005253 | FOS-like antigen 2 | FOSL2 | 1.865 | 1.647 | 1.389 | 1.634 |
| AL549027 | Fusion, derived from t(12;16) malignant liposarcoma | FUS | 2.083 | 1.290 | 1.524 | 1.633 |
| AI394426 | Mitogen-activated protein kinase 11 | MAPK11 | 1.941 | 1.318 | 1.610 | 1.623 |
| AU125722 | Phosphoprotein regulated by mitogenic pathways | C8FW | 1.979 | 1.508 | 1.354 | 1.613 |
| AI636054 | Bcl-2-associated transcription factor | BTF | 1.880 | 1.523 | 1.362 | 1.588 |
| AW955286 | Mago-Nashi homolog, proliferation associated (Drosophila) | MAGOH | 1.651 | 1.584 | 1.516 | 1.584 |
| AW275000 | Translocated promoter region (to activated MET oncogene) | TPR | 1.707 | 1.672 | 1.369 | 1.583 |
| AL544297 | Interferon-induced protein with tetratricopeptide repeats 4 | IFIT4 | 1.556 | 1.714 | 1.470 | 1.580 |
| BG256659 | CDC20 cell division cycle 20 homolog (S. cerevisiae) | CDC20 | 1.910 | 1.221 | 1.595 | 1.575 |
| AI992326 | Protein phosphatase 1G, magnesium dependent, gamma isoform | PPM1G | 1.829 | 1.661 | 1.230 | 1.573 |
| AU146354 | Cell division cycle 42 (GTP-binding protein; 25 kDa) | CDC42 | 1.676 | 1.802 | 1.224 | 1.567 |
| AU118099 | TAF15 RNA polymerase II, TATA box-binding protein-associated factor | TAF15 | 1.929 | 1.194 | 1.572 | 1.565 |
| BG036342 | Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70-interacting protein) | ST13 | 1.824 | 1.314 | 1.527 | 1.555 |
| NM_001706 | B-cell CLL/lymphoma 6 (zinc finger protein 51) | BCL6 | 1.000 | 1.549 | 1.552 | 1.550 |
| BC001149 | Serologically defined colon cancer antigen 16 | SDCCAG16 | 1.502 | 1.602 | 1.532 | 1.546 |
| AV742224 | 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) | L7a | 1.424 | 1.504 | 1.707 | 1.545 |
| BG532217 | Rab geranylgeranyltransferase, beta subunit | RABGGTB | 1.632 | 1.496 | 1.501 | 1.543 |
| AI207650 | APEX nuclease (multifunctional DNA repair enzyme) 1 | APEX1 | 1.277 | 1.809 | 1.507 | 1.531 |
| AV747778 | v-Fos FBJ murine osteosarcoma viral oncogene homolog | FOS | 1.512 | 1.797 | 1.283 | 1.531 |
| AW020536 | Bromodomain containing 8 | BRD8 | 1.542 | 1.543 | 1.449 | 1.511 |
| AI884571 | Splicing factor (45 kDa) | SPF45 | 1.208 | 1.732 | 1.579 | 1.506 |
| AL524788 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | RAD51 | 1.618 | 1.557 | 1.344 | 1.506 |
| D87461 | BCL2 like 2 | BCL2L2 | 1.365 | 1.585 | 1.559 | 1.503 |
| NM_006769 | LIM domain only 4 | LMO4 | 1.541 | 1.338 | 1.550 | 1.476 |
| BG475196 | E1A-binding protein p400 | EP400 | 1.510 | 1.595 | 1.316 | 1.474 |
| AA167701 | G-protein pathway suppressor 2 | GPS2 | 1.713 | 1.150 | 1.509 | 1.458 |
a
The numbers in columns K, L, and M represent the relative expression ratios from three replicate hybridizations (K, L, and M) with three independent RNA extractions. The median expression ratio can be read directly. “Mean” shows the arithmetic means of the relative expression ratios of experiments (K, L, and M) and provides additional statistical information. Note that genes are arranged according to the arithmetic means. Complete lists of >1.5-fold and <0.66-fold differentially expressed genes can be found at http://www.bordet.be/servmed/martiat/avdb/data.htm.