TABLE 7.
Redox-sensitive and glucocorticoid-induced genes up-regulated at late stage (60 h) of PRV151 infectiona
| Gene product | Designation | Tissue (fold increase) | Redox sensitive | GR inducible | Reference(s) |
|---|---|---|---|---|---|
| B-cell translocation gene 2 | Btg2 | Cer (2.0) | + | − | 59 |
| FBJ murine osteosarcoma viral oncogene homolog | Fos | Cer (3.4) | + | − | ROS-TRRDb |
| Crystallin, alpha B | Cryab | Hyp (2.2) | + | + | 26, 57 |
| Dual-specificity phosphatase 1 | Dusp1 | Cer (6.6) | + | + | ROS-TRRD, 74 |
| Hyp (7.1) | + | + | |||
| Glycerol-3-phosphate dehydrogenase 1 | Gpd1 | Hyp (14.7) | − | + | 38 |
| Metallothionein 1a | Mt1a | Cer (2.1) | + | + | ROS-TRRD, GR-TRRDc |
| Metallothionein 2 | Mt2 | Cer (12.7) | + | + | ROS-TRRD, GR-TRRD |
| Mitogen-inducible gene 6 protein homolog (gene 33) | Mig-6 | Cer (2.2) | − | + | 76 |
| Hyp (3.1) | − | + | |||
| Nuclear factor of kappa light-chain gene enhancer in B-cells inhibitor, alpha | Nfkbia | Hyp (2.1) | − | + | 15 |
| Serum/glucocorticoid-regulated kinase | Sgk | Cer (2.2) | + | + | 33 |
| Hyp (6.4) | + | + | |||
| Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | Sult1a1 | Cer (2.6) | − | + | 22 |
| Hyp (3.7) | − | + |
a
GR, glucocorticoid receptor; Cer, cerebellum; Hyp, hypothalamus.
b
ROS-TRRD, Redox-sensitive gene transcription regulatory regions database (http://wwwmgs.bionet.nsc.ru/mgs/papers/stepanenko/ros-trrd/).
c
GR-TRRD, Glucocorticoid-regulated transcription regulatory regions database (http://wwwmgs.bionet.nsc.ru/mgs/papers/merkulova/gluc/).