TABLE 4.
Detection of NiV RNA by RT-PCR in different organs of infected hamsters that had received different amounts of anti-G or anti-F NiV MAbsa
| Tested organ or sample | Detection of NiV RNA with the following MAb at the indicated day after infectionb
|
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No MAb (control)
|
Nip GIP 1.7 (anti-NiV.G MAb)
|
Nip GIP 35 (anti-NiV.F MAb)
|
|||||||||||||||||
| 112 μg | 1.12 μg | 0.112 μg
|
0.0112 μg
|
0.00112 μg
|
180 μg
|
1.8 μg
|
0.18 μg
|
0.018 μg
|
0.0018 μg
|
||||||||||
| D6 | D7 | D36 | D36 | D11 | D36 | D11 | D36 | D7 | D36 | D36 | D11 | D36 | D7 | D8 | D7 | D13 | D6 | D8 | |
| Organs | |||||||||||||||||||
| Brain | + | + | − | − | + | − | + | − | + | − | − | + | − | + | + | + | + | + | + |
| Heart | + | + | − | − | − | − | − | − | + | − | − | + | − | + | + | + | + | + | + |
| Liver | + | + | − | − | − | − | + | − | + | − | − | + | − | + | + | + | + | + | + |
| Lung | + | + | − | − | − | − | + | − | + | − | − | + | − | + | + | + | + | + | + |
| Spleen | + | + | − | − | − | − | + | − | + | − | − | + | − | + | + | + | + | + | + |
| Kidney | + | + | − | − | + | − | + | − | + | − | − | + | − | + | + | + | + | + | + |
| Urine samples | + | + | − | − | − | − | − | − | + | − | − | + | − | + | + | + | + | + | + |
a
Hamsters protected by the MAbs were tested 36 days after infection, whereas the organs of the moribund animals were taken just prior to death.
b
+, NiV RNA detected; −, NiV RNA not detected. D6, day 6 after infection.