TABLE 1.
Mutations in selected lp mutants
| Mutant(s) | nt sequenced | Site | Mutation | Genea | Change (aa)b |
|---|---|---|---|---|---|
| lp11 | 1-35934 | 1797 | G→A | E1B-19K | Trp(28)→Ter |
| lp12 | 333-3614 | 1973 | G→A | E1B-19K | Gly(87)→Glu |
| lp19 | 1-35934 | 1740 | +T | E1B-19K | (E1B-19K-Frameshift-Ter)* |
| 17186 | G→C | L2 pV | Gln(214)→His | ||
| lp20 | 333-3614 | 1861 | G→T | E1B-19K | Glu(50)→Ter |
| lp26 | 159-2578 | 2044 | +G | E1B-19K-55K | E1B-19K(112)-55K(11-496) fusion |
| lp34, lp48 | 333-3614 | 2044 | |||
| lp36 | 333-3614 | 1923 | G→A | E1B-19K | Ala(71)→Thr |
| 1924 | G→A | Silent | |||
| 2001 | G→A | Silent | |||
| 2003 | G→A | Ser(97)→Asn | |||
| lp56 | 333-3614 | 1972-1973 | GG→AA | E1B-19K | Gly(87)→Lys |
| 2059 | G→A | E1B-19K | Asp(116)→Asn | ||
| E1B-55K | Gly(14)→Glu | ||||
| lp24 | 1-35934 | 1317 | G→A | E1A | Silent |
| 1319 | G→A | E1A | Arg(215)→Lys | ||
| 17971 | C→A | (L2-L3) | Silent | ||
| 28517 | A→T | E3 (12.5K-7.1K) | Silent | ||
| 34659 | T→C | E4-Orf3 | Glu(14)→Gly | ||
| 34661 | C→T | E4-Orf3 | Silent | ||
| lp30 | 1-35934 | 14650 | G→T | Penton base | Trp(165)→Leu |
| 23994 | G→T | (L3-E2A) | Silent | ||
| lp41 | 1-35934 | 32777 | G→A | Fiber | Glu(581)→Lys |
| lp53 | 1-35934 | 8299 | C→T | i-Leader | Gln(108)→Ter |
| E2B (Ad Pol) | Silent |
a
The mutations that are located between two protein coding regions or transcription units are indicated within parentheses. Pol, DNA polymerase.
b
The amino acid (aa) changes caused by the mutations are indicated within parentheses. *, see text.