TABLE 2.

Selection of up-regulated transcripts in hUPF2-silenced H2KD cells with their putative NMD-causing features

Gene product description	Gene product symbol	Putative NMD motif	Fold increase
Calcium channel, voltage-dependent, L-type, alpha 1D subunit	CACNA1D	5′ uORF	7.4
Hypothetical protein	FLJ22655	5′ uORF	5.1
Phosphorylase, glycogen, muscle	PYGM	5′ uORF	4.2
Protein tyrosine phosphatase, nonreceptor type 21	PTPN21	5′ uORF	3.5
Tumor necrosis factor receptor superfamily, member 11b	TNFRSF11B	5′ uORF	3.4
Transmembrane 4 superfamily member 12	TM4SF12	5′ uORF	2.8
Homo sapiens calcium channel beta 2a subunit	CACNB2	5′ uORF	2.8
Chromosome 10 open reading frame 28	C10ORF28	5′ uORF	2.5
Neuropilin 1	NRP1	5′ uORF	2.4
Bone morphogenetic protein 5	BMP5	5′ uORF	2.3
BCL2-associated athanogene	BAG1	5′ uORF	2.2
Chromosome 11 open reading frame 8	C11ORF8	5′ uORF	2.2
Transmembrane 4 superfamily member 3	TM4SF3	5′ uORF	2.2
KH domain containing, RNA binding, signal transduction associated 3	KHDRBS3	Downstream intron	4.9
Neogenin homolog 1 (chicken)	NEO1	Downstream intron	4.1
KH domain containing, RNA binding, signal transduction associated 3	KHDRBS3	PTC through alternative splicing	4.9
Sarcosin, sarcomeric muscle protein	KBTBD10	PTC through alternative splicing	2.8
Hypothetical protein	MDS018	PTC through alternative splicing	2.7
Down syndrome critical region gene 1	DSCR1	PTC through alternative splicing	2.4
Transferrin receptor 2	TFR2	PTC through alternative splicing	2.4
Tumor necrosis factor, alpha-induced protein 3	TNFAIP3	PTC through alternative splicing	2.4
Chromosome 11 open reading frame 8	C11ORF8	PTC through alternative splicing	2.2
BCL2-associated athanogene	BAG1	PTC through alternative splicing	2.2