TABLE 3.
Selection of down-regulated transcripts in hUPF2-silenced H2KD cells with their biological function
| Gene product description | Gene product symbol | Biological function(s) (GeneCards database) | Fold decrease |
|---|---|---|---|
| Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 | SERPINB5 | Tumor suppressor | 8.7 |
| Cytoplasmic FMR1 interacting protein 1 | CYFIP2 | p53-inducible protein | 6.1 |
| Ankyrin repeat domain 15 | ANKRD15 | Tumorigenesis of renal cell carcinoma | 5.5 |
| Calcium/calmodulin-dependent protein kinase II inhibitor alpha | PRO1489 | Probably kinase activity | 3.4 |
| Hairy/enhancer-of-split related with YRPW motif 1 | HEY1 | Transcription factor | 3.1 |
| Clusterin | CLU | Associated with programmed cell death (apoptosis) | 3.0 |
| UPF2 regulator of nonsense transcripts homolog (yeast) | UPF2 | RNA binding, protein biosynthesis | 2.3 |
| Transmembrane 4 superfamily member tetraspan | NET-6 | Putative signal transduction | 2.3 |