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. 2002 Dec;76(24):12974–12980. doi: 10.1128/JVI.76.24.12974-12980.2002

FIG. 2.

FIG. 2.

RNA (Northern) filter hybridization analysis of HBV transcripts in the livers of HBV transgenic mice. (A) Groups of three mice of each sex and genotype are shown. The GAPDH transcript was used as an internal control for the quantitation of the HBV 3.5- and 2.1-kb RNAs. The probes used were HBVayw genomic DNA plus GAPDH cDNA. −, HBV transgenic mice lacking the rat HNF3β transgene; +, HBV transgenic mice hemizygous for the rat HNF3β transgene. (B) Quantitative analysis of the HBV 3.5- and 2.1-kb RNA levels in HBV transgenic mice. The mean HBV 3.5- and 2.1-kb RNA levels plus standard deviations derived from six male rat HNF3β(−) HBV transgenic mice, six male rat HNF3β(+) HBV transgenic mice, seven female rat HNF3β(−) HBV transgenic mice, and four female rat HNF3β(+) HBV transgenic mice are shown. The lower levels of the HBV 3.5- and 2.1-kb RNA in the rat HNF3β-expressing HBV transgenic mice are statistically significantly different from their levels in the control rat HNF3β(−) HBV transgenic mice by a Student's t test (P < 0.05).