FIG. 2.

Two-dimensional surface-like map of the human B-cell epitopes present on the surface of HCV E2, as recognized by the monoclonal antibodies used in this study. Overlapping circles indicate reciprocal inhibition. Fabs endowed with VSV/HCV pseudotype-neutralizing activity are underlined. The putative region mediating the interaction between HCV E2 and the cellular target is indicated by the dotted-line square. The putative region recognized by neutralizing antibodies is indicated by a thick black circle. Due to modifications that can be induced by antigen-antibody interactions, this diagram does not correspond to the actual physical map. The map without neutralization data is derived from previously published work (4).