FIG. 1.

Effects of SAMMA on HIV infection of macrophages and PBMC. Primary macrophages were infected with the R5 laboratory isolate BaL (A) or the R5 clinical isolate BR/92/003 (C) in the presence of the indicated concentrations of SAMMA. Viral replication was monitored by determining supernatant HIV-1 p24 (Gag) protein by ELISA on day 7. (C and D) Primary CD4⁺ T cells were infected with the X4 laboratory isolate IIIB (B) or the X4 clinical isolate UG021 (D) in the presence or absence of SAMMA, and p24 was quantified on day 5. Results represent the average p24 concentrations from triplicate wells (error bars indicate standard deviation) and are representative of at least two independent experiments.