TABLE 1.
Genes that change by ≥5-fold in 4-week-old compared to 1-day-old uninfected mouse brains
| Gene family and gene name | Accession no. | Fold change | Gene family and gene name | Accession no. | Fold change | |
|---|---|---|---|---|---|---|
| Annexins | ||||||
| Annexin V | U29396 | 5.6 | ||||
| Actin/cytoskeleton | ||||||
| Tctex-1 | W15873 | −8.2 | ||||
| Beta-tubulin | AA098307 | −5.2 | ||||
| Connexin-30 | Z70023 | 6.3 | ||||
| Alpha-tubulin | M13444 | 6.5 | ||||
| Gelsolin | J04953 | 7.4 | ||||
| Apoptosis related | ||||||
| Caspase-3 | U54803 | −12.8 | ||||
| Calcium-binding proteins | ||||||
| Calbindin-D28K | M21531 | 5 | ||||
| Calcyclin | M37761 | 6.4 | ||||
| S100 beta protein | L22144 | 7.4 | ||||
| Cell cycle related | ||||||
| CDC25MM | L20899 | 7.5 | ||||
| Chemokines | ||||||
| Fractalkine | U92565 | 9.8 | ||||
| Extracellular matrix and cell adhesion | ||||||
| Nidogen | X14194 | −7.7 | ||||
| Tenascin | X56304 | −5.1 | ||||
| Similar to human cell adhesion kinase beta | AA175767 | 8.8 | ||||
| Nervous system related | ||||||
| 1. Neurotransmitters | ||||||
| Proenkephalin A | M13227 | 6.3 | ||||
| Telencephalin | U06483 | 10.5 | ||||
| GABA | X51986 | 36.0 | ||||
| 2. Synaptic function | ||||||
| SNAP25 | M22012 | 5.2 | ||||
| Syntaxin 4 | U76832 | 5.6 | ||||
| 3. Other | ||||||
| Unc-33-like phosphoprotein (Ulip) | X87817 | −16.1 | ||||
| Similar to human Doc-2 | W37024 | −5.7 | ||||
| N-copine | R74842 | 5.2 | ||||
| P24 | D83206 | 5.7 | ||||
| Neurofilament component H | M35131 | 5.9 | ||||
| GABA-a/BZ receptor | M63436 | 12.6 | ||||
| Neuronal pentraxin 1 (NP-1) | U62021 | 14.3 | ||||
| Myelin proteolipid protein (PLP) | X07215 | 14.7 | ||||
| Myelin-associated glycoprotein | M31811 | 15.3 | ||||
| Purkinje cell protein 2 (L7) | M21532 | 19.4 | ||||
| ZnT-3 | U76007 | 22.2 | ||||
| Myelin-oligodendrocyte glycoprotein | U64572 | 23.1 | ||||
| P400 protein | X15373 | 27.4 | ||||
| Similar to human MOBP | U81317 | 29.6 | ||||
| Oligodendrocyte-specific protein (OSP) | U19582 | 30.7 | ||||
| Nucleotide exchange factors | ||||||
| R-ras3 | AB004879 | 5.1 | ||||
| Tiam-1 | U05245 | 7 | ||||
| SKD-2 | U10120 | 8.7 | ||||
| Growth factors | ||||||
| CD-MPR | X64068 | 5.7 | ||||
| Colony-stimulating factor 1 receptor | X06368 | 5.9 | ||||
| IFN-pathway related | ||||||
| Similar to IFN-inducible protein 1-8U (human) | W20873 | −5.2 | ||||
| Ran | L32751 | 13.9 | ||||
| Ion channels | ||||||
| Shaker K+ channel beta | X97281 | 5.4 | ||||
| mbGIRK3 K+ channel | U11860 | 6.3 | ||||
| Voltage-gated Na+ channel (beta 1 subunit) | L48687 | 8.2 | ||||
| TYRO3 | U05683 | 10.1 | ||||
| Voltage-dependent K+ channel beta subunit | U31908 | 12.2 | ||||
| Voltage-gated K+ channel protein KV1.1 | Y00305 | 17.3 | ||||
| Lipocalins | ||||||
| Apolipoprotein D | L39123 | 26.1 | ||||
| Metabolism | ||||||
| Polysialic acid synthase | X83562 | −16.2 | ||||
| 5-Aminolevulinic acid synthase | M63244 | −11.1 | ||||
| Protein phosphatase 2A | AA065915 | −6.8 | ||||
| Glutathione S-transferase | AA638086 | 5.1 | ||||
| Aldehyde dehydrogenase | M74570 | 5.7 | ||||
| Aspartate aminotransferase | J02623 | 5.8 | ||||
| N1-acetyltransferase SSAT | L10244 | 6.1 | ||||
| Similar to human platelet 6-phosphofructokinase | AA072252 | 6.4 | ||||
| Similar to phosphatidylinositol 4,5-bisphosphate | AA638530 | 6.6 | ||||
| Hypoxanthine-guanine phosphoribosyltransferase | J00423 | 8.1 | ||||
| Carbonic anhydrase II | K00811 | 10.4 | ||||
| Glycerol-3-phosphate dehydrogenase | M13366 | 10.4 | ||||
| Similar to human glyoxalase II | W08455 | 13.3 | ||||
| Protease inhibitors | ||||||
| Cystatin B | U59807 | 5.1 | ||||
| Similar to human flastase inhibitor | AA145127 | 5.6 | ||||
| Similar to human HtrA | AA059662 | 7.3 | ||||
| Inter-alpha trypsin inhibitor, heavy chain 3 | X70393 | 7.5 | ||||
| Protein degradation | ||||||
| Cathepsin C | U89269 | 5.3 | ||||
| Cathepsin S | AA255186 | 7.5 | ||||
| MISCELLANEOUS | ||||||
| Parotid secretory protein (PSP) | X01697 | −19.6 | ||||
| Salivary protein 1 | X00349 | −18.9 | ||||
| CD24 antigen | X53825 | −14.4 | ||||
| Retinol-binding protein | AA049662 | 5 | ||||
| Human mitochondrial 75-kDa FeS protein | V00835 | 5.1 | ||||
| Prion protein | M13685 | 5.3 | ||||
| P-selectin glycoprotein ligand-1 (PSGL-1) | X91144 | 6.1 | ||||
| FK506-binding protein 13 (FKBP13) | M77831 | 6.9 | ||||
| Hrp12 | U50631 | 8.2 | ||||
| Histone H2A | Z30940 | 8.8 | ||||
| Alpha B crystallin | M63170 | 9.1 | ||||
| Prealbumin | D89076 | 9.9 | ||||
| Parvalbumin | X59382 | 37.3 | ||||
| Unknown | ||||||
| EST | W53443 | −10.9 | ||||
| EST | AA152671 | −8.4 | ||||
| EST | AA516966 | −5.4 | ||||
| EST | AA408420 | −5 | ||||
| EST | AA166452 | 5.4 | ||||
| EST | AA521958 | 5.5 | ||||
| EST | W41070 | 5.5 | ||||
| EST | R74735 | 6.1 | ||||
| EST | AA139510 | 8.3 | ||||
| EST | AA266791 | 8.4 | ||||
| EST | R74641 | 11.1 | ||||
| EST | R75354 | 19.8 | ||||
| EST | R75030 | 20.9 | ||||
| EST | AA673405 | 21.4 |