TABLE 4.
Vaccine | Monkey | % p11C tetramer-binding CD3+ CD8+ T lymphocytes
|
|
---|---|---|---|
Peripheral blood | Distal colon | ||
DNA/rMVAa | 135-97 | 1.39 | 0.66 |
DNA/rMVA | 128-97 | 1.04 | 0.68 |
DNA/rMVA | 90-98 | 0.34 | 0.34 |
DNA/rMVA | 95-98 | 0.33 | 0.15 |
DNA/rAd5b | AW2P | 2.30 | 1.00 |
DNA/rAd5 | AW28 | 2.46 | 1.75 |
Immunized with plasmid DNAs containing the SIVmac239 gag, pol, and nef and the HIV-1 89.6 env epitope genes and boosted with recombinant MVA vectors expressing SIV gag-pol and HIV-1 89.6 env.
Immunized with plasmid DNA containing the SIVmac239 gag-pol-nef and HIV-1 89.6P env gene and boosted with recombinant adenovirus serotype 5 constructs expressing the SIV gag-pol-nef and HIV-1 89.6P env genes.