FIG. 3.
Mamu-A*02 restricts SIV-derived CTL epitopes. Cells of the MHC class I-negative human B-lymphoblastoid cell line 721.221, transfected with Mamu-A*02 (Mamu-A*02.221) or Mamu-A*04 (Mamu-A*04.221), were pulsed with the appropriate peptide and used in the ICS assay, together with peptide-specific T-cell lines from animal 87082. Both T-cell lines specific for Gag71-79 GY9 (A) and for Nef159-167 YY9 (B) were stimulated by Mamu-A*02-transferents pulsed with the relevant peptide but not by Mamu-A*04 transferents.