TABLE 1.
Neutralization of clone R2-, MN-TCLA-, and MN-P-pseudotyped viruses by MAbs and sCD4a
| Envelope region | Antibody and/or ligand | Epitope | IC50 (μg/ml) for strain
|
||
|---|---|---|---|---|---|
| R2 | MN-TCLA | MN-P | |||
| V3 | 257D-IV | RIHIG | >0.5 | 0.01 | —b |
| 268D-IV | HIGPGR | >0.5 | 0.05 | — | |
| IIIB/V3-13 | IRIQRGPGR | >10 | — | — | |
| IIIB/V3-21 | INCTRPN | >10 | — | — | |
| R/V3-50-1 | RIHIG | >10 | ≤0.01 | — | |
| 19b | XIXXXXGXXFYXT | 1.7 | 1.0 | 10.0 | |
| 391/95D | KRIHIGPGRAFY | >10 | 0.01 | — | |
| 418-D | HIGPGRA | >10 | — | — | |
| 694/98-D | GRAF | 2.5 | 0.01 | >20 | |
| 447-52D | GPGR | >10 | <0.05 | — | |
| 838-D | KISITK | >10 | — | — | |
| 1027-D | KISITKGP | >10 | — | — | |
| CD4bs | F105 | Conformational | >10 | >100 | — |
| 15e | Conformational | 3.7 | 1.2 | >20 | |
| IgG1B12 | Conformational | 6.6 | 0.02 | 1.3 | |
| sCD4 | CD4bs | 0.28 | 0.11 | 5.2 | |
| CD4i | 4.8D | Conformational | 8.6 | 1.0 | >20 |
| 17b | Conformational | 9.4 | 5.0 | — | |
| gp41 | 2F5 | ELDKWA | 7.5 | 5.0 | — |
| Other | 2G12 | Unknown | 7.5 | >50 | — |